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The strongest evidence is preclinical but directly tests NNMT inhibition in metabolic disease models

Vitamin B12 injections are used to treat low B12 levels when diet or tablets are not enough

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It also contains a deletion of 70 amino acid residues from the C-terminus, a region that is highly flexible and that contains an immunodominant linear epitope that is strongly targeted by non-nAbs in convalescent COVID-19 plasma

In research models where caloric intake is unrestricted, this is typically well-tolerated

Vitamin injections are quickjust a few minutesand target specific vitamins like B12 or MIC